2. Signaling Pathways
  3. GPCR/G Protein
  4. Neuropeptide FF Receptor

Neuropeptide FF Receptor

Neuropeptide FF Receptor

Neuropeptide FF Receptor (NPFFR) is a type of G Protein-Coupled Receptor (GPCR) belonging to the RFamide receptor subfamily, specifically binding to neuropeptide FF (NPFF) and its analogous peptides (such as NPAF, NPSF).
NPFFR has two subtypes: NPFFR1 (GPR147) and NPFFR2 (GPR74), and these receptors regulate a variety of physiological functions, including modulation of pain, opioid side effects, feeding, drug reward, anxiety, cardiac function, and control of insulin release, among others.
Based on its pleiotropic functions, NPFFR is considered a potential target for the treatment of chronic pain, opioid dependence, metabolic diseases (such as obesity), and anxiety disorders[1][2].

Neuropeptide FF Receptor Isoform Specific Products:

Neuropeptide FF Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-P1248
    Neuropeptide FF
    		98.80%
    Neuropeptide FF (NPFF), an octapeptide belonging to the RF-amide family of peptides, interacts with two distinct G-protein-coupled receptors, NPFF(1) and NPFF(2) and has wide variety of physiological functions in the brain including central cardiovascular and neuroendocrine regulation.
    Neuropeptide FF
  • HY-124680
    AC-263093 free base
    		Inhibitor 99.81%
    AC-263093 free base (AC-093) functionally activates NPFFR2 and blocks activation of NPFFR1 with pKis of 6.9 and 7.0, respectively. AC-263093 free base has the potential for reversing opiate tolerance research.
    .
    AC-263093 free base
  • HY-154829A
    AC-099 hydrochloride
    		Agonist 99.92%
    AC-099 hydrochloride (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 hydrochloride attenuates spinal nerve ligation-induced hypersensitivity in rats.
    AC-099 hydrochloride
  • HY-P10395
    DP50
    		Antagonist
    DP50 is a bifunctional compound that contains an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. DP50 can be used in analgesia-related research.
    DP50
  • HY-P10377
    GUB03385
    		Agonist
    GUB03385 is a long-acting PrRP31 analogue. GUB03385 is a potent dual agonist for GPR10 (full agonist, EC50: 0.4 nM) and NPFF2R (partial agonist, EC50: 20 nM). GUB03385 has anti-obesity effect.
    GUB03385
  • HY-P10780
    RFRP-3 (mouse)
    		Modulator
    RFRP-3 (mouse) is a functional ortholog of avian gonadotropin inhibitory hormone (GnIH), binding to GPR147. RFRP-3 (mouse) reduces Progesterone synthesis by inhibiting FSHR and key enzymes involved in steroidogenesis (P450scc, 3β-HSD, StAR). RFRP-3 (mouse) induces Apoptosis (increase of p53). RFRP-3 (mouse) also suppresses the ERK signaling pathway. RFRP-3 (mouse) can be used for research of follicular development.
    RFRP-3 (mouse)
  • HY-P10379
    palm-PrRP31
    		Agonist
    palm-PrRP31 is a potent dual receptor agonist for both GPR10 (EC50=72 pM) and NPFF-R2. palm-PrRP31 activates downstream signaling pathways through binding to its receptors, GPR10 and NPFF-R2, which results in reduced appetite and increased energy expenditure. Utilizing palm-PrRP31 facilitates the study of the mechanism of action in the nervous system, thereby elucidating the complex biological processes that regulate appetite and energy expenditure.
    palm-PrRP31
  • HY-P3873
    Neuropeptide FF (5-8)
    Neuropeptide FF (5-8) is a Neuropeptide FF (HY-P1248)-related peptide. Neuropeptide FF (5-8) with a sequence of Q-P-Q-R-F-NH2 and a Ki value of 20.9 nM.
    Neuropeptide FF (5-8)
  • HY-P3945
    Prolactin-Releasing Peptide (12-31), bovine
    Prolactin-Releasing Peptide (12-31), bovine is a peptide fragment of prolactin-releasing peptide (PrRP). PrRP is RF-amide peptides expressed in brain areas involved in pain modulation. Prolactin-Releasing Peptide (12-31), bovine can be used for the research of nervous system disease.
    Prolactin-Releasing Peptide (12-31), bovine
  • HY-P10380
    palm11-PrRP31
    		Agonist
    palm11-PrRP31 is a lipidized endogenous appetite inhibitory neuropeptide (PrRP) analogue. palm11-PrRP31 is GPR10 (EC50=39 pM) and NPFF-R2 effective dual agonists. palm11-PrRP31 is able to mimic the natural function of PrRP by binding to these receptors to reduce food intake. palm11-PrRP31 can be used as a potential anti-obesity agent and for the study of neuropeptide-receptor interaction.
    palm11-PrRP31
  • HY-P10394
    DP32
    		Antagonist
    DP32 is a bifunctional compound that contains an opioid receptor (MOP) agonist and a neuropeptide FF receptor (NPFFR) antagonist. DP32 can be used in analgesia-related research.
    DP32
  • HY-161405
    NPFF1-R antagonist 1
    		Inhibitor
    NPFF1-R antagonist 1 (compound 8b), a piperidine analogue, is a potent neuropeptide FF (NPFF) receptor antagonist. NPFF1-R antagonist 1 is 15-fold selective for the NPFF1-R subtype, with Ki values of 211 nM and 3270 nM for NPFF1-R and NPFF2-R, respectively.
    NPFF1-R antagonist 1
  • HY-154829
    AC-099
    		Agonist
    AC-099 (compound 3) is a selective NPFF2R full agonist (EC50=1189 nM) and NPFF1R partial agonist (EC50=2370 nM). AC-099 attenuates spinal nerve ligation-induced hypersensitivity in rats.
    AC-099
  • HY-161382
    NPFF2-R ligand 1
    		Ligand
    NPFF2-R ligand 1 (Compound 16a) is a NPFF2-R ligand, with Kis of 228 and 27 nM for NPFF1-R and NPFF2-R respectively. NPFF2-R ligand 1 can be used for research related with central nervous system.
    NPFF2-R ligand 1
Neuropeptide FF Receptor Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.